A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy. (18th February 2014)

• Record Type: Journal Article
• Authors: Liang, Ruizheng; Tian, Rui; Ma, Lina; Zhang, Lele; Hu, Yanli; Wang, Jian; Wei, Min; Yan, Dan; Evans, David G.; Duan, Xue
• Is Part Of: Advanced functional materials. Volume 24:Number 21(2014)
• Page Start: 3144
• Page End: 3151
• Publication Date: 2014-02-18
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201303811
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A supermolecular photosensitizer with excellent anticancer behavior when used for photodynamic therapy (PDT) is fabricated by the incorporation of zinc phthalocyanines (ZnPc) into the gallery of a layered double hydroxide (LDH). The composite material possesses uniform particle size (hydrodynamic diameter ∼120 nm), and the host–guest and guest–guest interactions result in a high dispersion of ZnPc in a monomeric state in the interlayer region of the LDH matrix, with high singlet oxygen production efficiency. In vitro tests performed with HepG2 cells reveal a satisfactory PDT effectiveness of the ZnPc(1.5%)/LDH composite photosensitizer: a cellular damage as high as 85.7% is achieved with a rather low dosage of ZnPc (10 μg/mL). An extraordinarily high specific efficacy is demonstrated (31.59 μg<sup>−1</sup> (J/cm<sup>2</sup>)<sup>−1</sup>), which is over 185.5% enhancement compared with the previously reported photosensitizers under similar test conditions. Furthermore, an in vivo study of the ZnPc(1.5%)/LDH demonstrates excellent PDT performance with an ultra‐low dose (0.3 mg/kg) and a low optical fluence rate (54 J/cm<sup>2</sup>). In addition, the ZnPc/LDH photosensitizer displays high stability, good biocompatibility, and low cytotoxicity, which would guarantee its practical application. Therefore, this work provides a facile approach for design and fabrication of inorganic–organic supermolecular materials with greatly enhanced anticancer behavior.</p> </abstract>