Inflammation‐based prognostic score is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma. Issue 3 (March 2013)

• Record Type: Journal Article
• Authors: Oshiro, Yukio; Sasaki, Ryoko; Fukunaga, Kiyoshi; Kondo, Tadashi; Oda, Tatsuya; Takahashi, Hideto; Ohkohchi, Nobuhiro
• Is Part Of: Journal of hepato-biliary-pancreatic sciences. Volume 20:Issue 3(2013)
• Page Start: 389
• Page End: 395
• Publication Date: 2013-03
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 617.556
• DOI: 10.1007/s00534-012-0550-6
• Languages: English
• ISSNs: 1868-6974

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jhbp2017-sec-0001" sec-type="section"> <title>Background/purpose</title> <p>Recent studies have revealed that the Glasgow prognostic score (GPS), an inflammation‐based prognostic score, is useful for predicting outcome in a variety of cancers. This study sought to investigate the significance of GPS for prognostication of patients who underwent surgery with extrahepatic cholangiocarcinoma.</p> </sec> <sec id="jhbp2017-sec-0002" sec-type="section"> <title>Methods</title> <p>We retrospectively analyzed a total of 62 patients who underwent resection for extrahepatic cholangiocarcinoma. We calculated the GPS as follows: patients with both an elevated C‐reactive protein (>10 mg/L) and hypoalbuminemia (<35 g/L) were allocated a score of 2; patients with one or none of these abnormalities were allocated a score of 1 or 0, respectively. Prognostic significance was analyzed by the log‐rank test and a Cox proportional hazards model.</p> </sec> <sec id="jhbp2017-sec-0003" sec-type="section"> <title>Results</title> <p>Overall survival rate was 25.5 % at 5 years for all 62 patients. Venous invasion (<italic>p</italic> = 0.01), pathological primary tumor category (<italic>p</italic> = 0.013), lymph node metastasis category (<italic>p</italic> < 0.001), TNM stage (<italic>p</italic> < 0.001), and GPS (<italic>p</italic> = 0.008) were significantly associated with survival by univariate analysis. A Cox model demonstrated that increased GPS was an independent predictive factor with poor prognosis.</p> </sec> <sec id="jhbp2017-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The preoperative GPS is a useful predictor of postoperative outcome in patients with extrahepatic cholangiocarcinoma.</p> </sec> </abstract>