The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. (8th April 2014)

• Record Type: Journal Article
• Authors: Daud, Norlida M.; Ismail, Nurhafzan A.; Thomas, Elizabeth L.; Fitzpatrick, Julie A.; Bell, Jimmy D.; Swann, Jonathan R.; Costabile, Adele; Childs, Caroline E.; Pedersen, Camilla; Goldstone, Anthony P.; Frost, Gary S.
• Is Part Of: Obesity. Volume 22:Number 6(2014:Jun.)
• Page Start: 1430
• Page End: 1438
• Publication Date: 2014-04-08
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20754
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20754-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers.</p> </sec> <sec id="oby20754-sec-0002" sec-type="section"> <title>Methods</title> <p>In a parallel, single‐blind and placebo‐controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day<sup>−1</sup> oligofructose or cellulose for 6 weeks following a 2‐week run‐in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post‐supplementation.</p> </sec> <sec id="oby20754-sec-0003" sec-type="section"> <title>Results</title> <p>Oligofructose increased breath hydrogen (<italic>P</italic> < 0.0001), late acetate concentrations (<italic>P</italic> = 0.024), tended to increase total area under the curve (tAUC)<sub>420mins</sub> peptide YY (PYY) (<italic>P</italic> = 0.056) and reduced tAUC<sub>450mins</sub> hunger (<italic>P</italic> = 0.034) and motivation to eat (<italic>P</italic> = 0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon‐like peptide 1 (GLP‐1) (<italic>P</italic> = 0.006) in the cellulose group and a decrease in EI during <italic>ad libitum</italic> meal in both groups.</p> </sec> <sec id="oby20754-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP‐1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.</p> </sec> </abstract>