An Efficient Microwave‐Assisted Synthesis and Antimicrobial Activity of Novel 2‐Amino 3‐Cyano Pyridine Derivatives using Two Reusable Solid Acids as Catalysts. (22nd November 2013)

• Record Type: Journal Article
• Authors: Thakrar, Shailesh; Bavishi, Abhay; Radadiya, Ashish; Vala, Hardevsinh; Parekh, Shrey; Bhavsar, Dhairya; Chaniyara, Ravi; Shah, Anamik
• Is Part Of: Journal of heterocyclic chemistry. Volume 51:Number 3(2014)
• Page Start: 555
• Page End: 561
• Publication Date: 2013-11-22
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1641
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Two solid acids, Fe<sup>3+</sup> K‐10 montmorillonite clay and HY‐zeolite, have been employed efficiently for synthesis of 2‐amino 3‐cyano pyridines <bold>4a</bold>, <bold>4b</bold>, <bold>4c</bold>, <bold>4d</bold>, <bold>4e</bold>, <bold>4f</bold>, <bold>4g</bold>, <bold>4h</bold>, <bold>4i</bold>, <bold>4j</bold>, <bold>4k</bold>, <bold>4l</bold>, <bold>4m</bold>, <bold>4n</bold>, <bold>4o</bold>, <bold>4p</bold>, <bold>4q</bold>, <bold>4r</bold>, <bold>4s</bold>, <bold>4t</bold>, <bold>4u</bold>, <bold>4v</bold>, <bold>4w</bold>, <bold>4x</bold> by <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">multicomponent reaction</named-content> of 3‐acetyl 4‐hydroxy coumarin <bold>1a</bold>, <bold>1b</bold>, <bold>1c</bold>, 1, 3‐diphenyl‐1<italic>H</italic>‐pyrazole‐4‐carbaldehyde <bold>2a</bold>, <bold>2b</bold>, <bold>2c</bold>, <bold>2d</bold>, <bold>2e</bold>, <bold>2f</bold>, <bold>2g</bold>, <bold>2h</bold>, malononitrile <bold>3</bold>, and ammonium acetate. Both the catalysts are recoverable and recyclable. The main significant of this procedure is short reaction time, high yields, easy workup procedure, and being environmentally friendly. The structures of all the compounds have been well characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and mass spectral data. All the synthesized compounds were screened for their antimicrobial and antifungal activities.</p> </abstract>