1, 8‐Diazabicyclo[5.4.0]undec‐7‐ene: A Highly Efficient Catalyst for One‐Pot Synthesis of Substituted Tetrahydro‐4H‐chromenes, Tetrahydro[b]pyrans, Pyrano[d]pyrimidines, and 4H‐Pyrans in Aqueous Medium. (27th November 2013)

• Record Type: Journal Article
• Authors: Khurana, Jitender M.; Nand, Bhaskara; Saluja, Pooja
• Is Part Of: Journal of heterocyclic chemistry. Volume 51:Number 3(2014)
• Page Start: 618
• Page End: 624
• Publication Date: 2013-11-27
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.1507
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We have reported 1, 8‐diazabicyclo[5.4.0]undec‐7‐ene catalyzed <named-content content-type="reactionType" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">one‐pot synthesis</named-content> of tetrahydro‐4<italic>H</italic>‐chromenes, tetrahydro[<italic>b</italic>]pyrans, pyrano[<italic>d</italic>]pyrimidines and 4<italic>H</italic>‐pyrans from aldehydes, active methylene compounds malononitrile/ethyl cyanocacetate and activated C–H acids such as dimedone, 1, 3‐cyclohexanedione, 1, 3‐cyclopentanedione, 1, 3‐dimethylbarbituric acid, and ethyl acetoacetate in water under reflux. The attractive features of this process are mild reaction conditions, reusability of the reaction media, short reaction times, easy isolation of products, and excellent yields. Copyright © 2013 HeteroCorporation</p> </abstract>