Saccharomyces cerevisiae Rif1 cooperates with MRX‐Sae2 in promoting DNA‐end resection. (1st April 2014)

• Record Type: Journal Article
• Authors: Martina, Marina; Bonetti, Diego; Villa, Matteo; Lucchini, Giovanna; Longhese, Maria Pia
• Is Part Of: EMBO reports. Volume 15:Number 6(2014:Jun.)
• Page Start: 695
• Page End: 704
• Publication Date: 2014-04-01
• Subjects: Molecular biology -- Periodicals; Molecular Biology -- Periodicals; Molecular biology; Periodicals; 572.8
• DOI: 10.1002/embr.201338338
• Languages: English
• ISSNs: 1469-221X

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embr201338338-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embr201338338-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pghctmtwb4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Rif1 promotes nucleolytic processing of DNA double‐strand breaks in <italic>S. cerevisiae</italic> via a pathway that is partially redundant with the one involving Sae2 and Exo1.</p> <p> <list id="embr201338338-list-0006" list-type="bullet"> <list-item> <p> <italic>Saccharomyces cerevisiae</italic> Rif1 supports cell viability in the absence of the MRX complex.</p> </list-item> <list-item> <p>Rif1 promotes resection of DNA double‐strand breaks.</p> </list-item> <list-item> <p>Lack of Rad9 suppresses the resection defect of <italic>rif1∆</italic> cells and the growth defect of <italic>rif1∆ mre11∆</italic> cells.</p> </list-item> </list> </p> </abstract>