Impact of haplotypes of TNF in the natural course of infective endocarditis. (25th October 2013)

• Record Type: Journal Article
• Authors: Giannitsioti, E.; Damoraki, G.; Rokkas, C.; Tsaganos, T.; Fragou, A.; Kannelaki, S.; Athanasia, S.; Giamarellos‐Bourboulis, E. J.; Grobusch, M.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 5(2014:May)
• Page Start: 459
• Page End: 464
• Publication Date: 2013-10-25
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12370
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12370-abs-0001"> <title>Abstract</title> <p>Based on previous findings for the role of single nucleotide polymorphisms (SNPs) of <italic>TNF</italic> for the predisposition for bloodstream infections, this study investigates the role of these SNPs at the promoter positions −376, −308, −238 in infective endocarditis (IE). In a case–control study, 83 patients with IE and 83 controls were enrolled. Blood genotyping for the presence of G or A alleles of the three SNPs was carried out using restriction fragment length polymorphisms. Haplotypes were calculated. Patients were mostly infected by <italic>Staphylococcus aureus</italic> (32.5%) and by species of enterococci (14.3%) and streptococci (14.3%). Carriage of the minor frequency A alleles at −238 of the promoter region of <italic>TNF</italic> was greater than in controls (8.4% versus 1.2%, p 0.003). The presence of any of the three GGA/GAA/AGA haplotypes was more frequent in patients with IE (OR 8.22, 95CI% 1.8–37.4, p 0.001). After multivariate logistic regression analysis, it was found that the only factor related to fatal outcome was carriage of the wild‐type GGG haplotype (OR, 3.29, 95CI%, 1.05–10.29, p 0.04). GGA, AGA and GAA haplotypes were more frequent in patients with IE than in controls, suggesting a predisposition for IE and a potential protective role against fatal outcome, as the wild‐type GGG haplotype was independently related with death.</p> </abstract>