The Clostridium difficile PCR ribotype 027 lineage: a pathogen on the move. (28th April 2014)

• Record Type: Journal Article
• Authors: Valiente, E.; Cairns, M. D.; Wren, B. W.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 5(2014:May)
• Page Start: 396
• Page End: 404
• Publication Date: 2014-04-28
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12619
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12619-abs-0001"> <title>Abstract</title> <p> <italic>Clostridium difficile</italic> is a Gram‐positive, spore‐forming, human and animal pathogen that is the major cause of antibiotic‐associated diarrhoea worldwide. The past decade has seen the rapid emergence of the hypervirulent PCR ribotype (RT) 027 complex, which has been associated with increases in the incidence and severity of disease and mortality. In this review, we describe the potential virulence factors that have been reported in strains from the RT 027 complex. We review the emergence, population structure, dissemination and evolution of this lineage.</p> </abstract>