Crystal Structures of Acyl Carrier Protein in Complex with Two Catalytic Partners Show a Dynamic Role in Cellular Metabolism. Issue 8 (25th April 2014)

• Record Type: Journal Article
• Authors: Newmister, Sean A.; Sherman, David H.
• Is Part Of: Chembiochem. Volume 15:Issue 8(2014)
• Page Start: 1079
• Page End: 1081
• Publication Date: 2014-04-25
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201402095
• Languages: English
• ISSNs: 1439-4227

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>ACP captured in action:</bold> Two recently reported crystal structures are the first to capture ACP‐mediated substrate delivery to a catalytic partner at high resolution. These studies highlight key interactions of transient ACP–partner complexes and define the dynamic movements of ACP that facilitate substrate delivery and trigger complex dissociation.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgh7g00m0q" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>