Potential therapeutic use of herbal extracts in trypanosomiasis. (January 2014)

• Record Type: Journal Article
• Authors: Teixeira, Thaise L.; Teixeira, Samuel Cota; Silva, Claudio Vieira da; Souza, Maria A. de.
• Is Part Of: Pathogens and global health. Volume 108:Number 1(2014)
• Page Start: 30
• Page End: 36
• Publication Date: 2014-01
• Subjects: Communicable diseases -- Periodicals; Public health -- International cooperation -- Periodicals; World health -- Periodicals; 362.1969
• DOI: 10.1179/2047773213Y.0000000120
• Languages: English
• ISSNs: 2047-7724

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <p>The aim of the present study was to evaluate the effects of crude extracts from <italic>Handroanthus impetiginosa</italic>, <italic>Ageratum conyzoides</italic>, and <italic>Ruta graveolens</italic> on <italic>Leishmania amazonensis</italic> and <italic>Trypanosoma cruzi</italic> infection <italic>in vitro.</italic> The results showed that the extracts caused significant toxicity in promastigotes and trypomastigotes. A significant decrease in the rate of cell invasion by pretreated trypomastigotes and promastigotes was also observed. The extracts caused a significant reduction of the multiplication of intracellular amastigotes of both parasites. Therefore, these herbal extracts may be potential candidates for the development of drugs for the treatment of leishmaniasis and Chagas disease.</p> </abstract>