Postantibiotic effect of disinfection treatment by photolysis of hydrogen peroxide. (April 2014)

• Record Type: Journal Article
• Authors: Odashima, Yu; Nakamura, Keisuke; Ikai, Hiroyo; Kanno, Taro; Meirelles, Luiz; Sasaki, Keiichi; Niwano, Yoshimi
• Is Part Of: Journal of chemotherapy. Volume 26:Number 2(2014:Apr.)
• Page Start: 92
• Page End: 100
• Publication Date: 2014-04
• Subjects: Chemotherapy -- Periodicals; Drug Therapy -- Periodicals; 615.58
• DOI: 10.1179/1973947813Y.0000000114
• Languages: English
• ISSNs: 1120-009X

Abstract

<abstract> <title> <x content-type="archive" xml:space="preserve">Abstract</x> </title> <sec> <p>The purpose of the present study was to evaluate the postantibiotic effect (PAE) of the disinfection treatment by photolysis of H₂O₂. Postantibiotic effect was induced in <italic>Staphylococcus aureus</italic> and <italic>Streptococcus salivarius</italic> by exposing the bacteria to H₂O₂ at concentrations of 250–1000 mmol/l, laser irradiation at a wavelength of 405 nm, and the combination of both (photolysis of H₂O₂) for 10–30 seconds. The photolysis of H₂O₂ induced significantly longer PAE than other treatments. The PAE was augmented dependently on not only the concentration of H₂O₂ but the laser irradiation time. Electron spin resonance analysis showed that the hydroxyl radical was also generated dependently on both the concentration of H₂O₂ and the laser irradiation time, suggesting that the hydroxyl radicals contribute to the PAE. These results suggest that the disinfection treatment by photolysis of H₂O₂ induces PAE in <italic>S. aureus</italic> and <italic>S. salivarius</italic> even though they were treated for only 10–30 seconds.</p> </sec> </abstract>