Noncovalent Chirality Sensing Ensembles for the Detection and Reaction Monitoring of Amino Acids, Peptides, Proteins, and Aromatic Drugs1. Issue 22 (9th April 2014)

• Record Type: Journal Article
• Authors: Biedermann, Frank; Nau, Werner M.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 22(2014)
• Page Start: 5694
• Page End: 5699
• Publication Date: 2014-04-09
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201400718
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Ternary complexes between the macrocyclic host cucurbit[8]uril, dicationic dyes, and chiral aromatic analytes afford strong induced circular dichroism (ICD) signals in the near‐UV and visible regions. This allows for chirality sensing and peptide‐sequence recognition in water at low micromolar analyte concentrations. The reversible and noncovalent mode of binding ensures an immediate response to concentration changes, which allows the real‐time monitoring of chemical reactions. The introduced supramolecular method is likely to find applications in bioanalytical chemistry, especially enzyme assays, for drug‐related analytical applications, and for continuous monitoring of enantioselective reactions, particularly asymmetric catalysis.</p> </abstract>