Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors. (29th October 2013)

• Record Type: Journal Article
• Authors: Lee, Young Bok; Kim, Hee Jung; Jung, Hwa Young; Park, Yong Gyu; Kim, Si Yong; Cho, Baik Kee; Cho, Daeho; Park, Hyun Jeong
• Is Part Of: International journal of dermatology. Volume 53:Number 6(2014:Jun.)
• Page Start: 723
• Page End: 730
• Publication Date: 2013-10-29
• Subjects: Dermatology -- Periodicals; 616.5
• DOI: 10.1111/ijd.12057
• Languages: English
• ISSNs: 0011-9059

Abstract

<abstract abstract-type="main" id="ijd12057-abs-0001"> <title>Summary</title> <sec id="ijd12057-sec-0001" sec-type="section"> <title>Background</title> <p>Erythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors.</p> </sec> <sec id="ijd12057-sec-0002" sec-type="section"> <title>Methods</title> <p>To investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant<sup>™</sup> software.</p> </sec> <sec id="ijd12057-sec-0003" sec-type="section"> <title>Results</title> <p>Erythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma.</p> </sec> <sec id="ijd12057-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.</p> </sec> </abstract>