A New Golden Age for Donor–Acceptor Cyclopropanes. Issue 22 (25th April 2014)

• Record Type: Journal Article
• Authors: Schneider, Tobias F.; Kaschel, Johannes; Werz, Daniel B.
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 22(2014)
• Page Start: 5504
• Page End: 5523
• Publication Date: 2014-04-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201309886
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The effective use of ring strain has been applied to considerable advantage for the construction of complex systems. The focus here is directed towards cyclopropanes as building blocks for organic synthesis. Although thermodynamics should take the side of synthetic chemists, only a specific substitution pattern at the cyclopropane ring allows for particularly mild, efficient, and selective transformations. The required decrease in the activation barrier is achieved by the combined effects of vicinal electron‐donating and electron‐accepting moieties. This Review highlights the appropriate tools for successfully employing donor–acceptor cyclopropanes in ring‐opening reactions, cycloadditions, and rearrangements.</p> </abstract>