Parthenium dermatitis: is parthenolide an effective choice for patch testing?. (11th March 2014)

• Record Type: Journal Article
• Authors: Mahajan, Vikram K.; Sharma, Vikas; Gupta, Mrinal; Chauhan, Pushpinder S.; Mehta, Karaninder S.; Garg, Swati
• Is Part Of: Contact dermatitis. Volume 70:Number 6(2014:Jun.)
• Page Start: 340
• Page End: 343
• Publication Date: 2014-03-11
• Subjects: Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.12194
• Languages: English
• ISSNs: 0105-1873

Abstract

<abstract abstract-type="main" id="cod12194-abs-0001"> <title>Summary</title> <sec id="cod12194-sec-0001" sec-type="section"> <title>Background</title> <p id="cod12194-para-0001">Patch test positivity to parthenolide was observed less often than expected in strongly suspected cases of parthenium dermatitis after Chemotechnique Diagnostics (Sweden) replaced parthenium extract with parthenolide (0.5% pet.) by itself while marketing its Indian baseline series for patch testing.</p> </sec> <sec id="cod12194-sec-0009" sec-type="section"> <title>Objective</title> <p id="cod12194-para-0013">The study was performed to find whether parthenolide detects parthenium contact sensitivity more effectively than parthenium extract in patients clinically presenting with classic parthenium dermatitis.</p> </sec> <sec id="cod12194-sec-0002" sec-type="section"> <title>Material and methods</title> <p id="cod12194-para-0002">One hundred consecutive patients with suspected parthenium dermatitis were patch tested prospectively with the Indian baseline series, parthenium extract (1% aq.) and parthenolide (0.5% pet.) between July 2011 and April 2012.</p> </sec> <sec id="cod12194-sec-0003" sec-type="section"> <title>Results</title> <p id="cod12194-para-0003">Only 37 of 100 patients with suspected parthenium dermatitis (male/female ratio of 20:17) reacted to parthenium extract (32 patients), parthenolide (17 patients), or both (12 patients). Reactions to parthenium extract were generally stronger than reactions to parthenolide.</p> </sec> <sec id="cod12194-sec-0004" sec-type="section"> <title>Conclusion</title> <p id="cod12194-para-0004">Patch testing with parthenolide (0.5% pet.) detects fewer cases of suspected parthenium dermatitis than patch testing with parthenium extract (1% aq.).</p> </sec> </abstract>