Iron deficiency state in resistant oral aphthosis of Behcet's disease. (28th January 2013)

• Record Type: Journal Article
• Authors: Dormohammadi Toosi, Taraneh; Shahram, Farhad; Ghodsi, S. Zahra; Nadji, Abdolhadi; Tehrani Banihashemi, Arash; Larimi, Seyyedeh Roghieh; Davatchi, Fereydoun
• Is Part Of: International journal of rheumatic diseases. Volume 17:Number 4(2014)
• Page Start: 425
• Page End: 429
• Publication Date: 2013-01-28
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12045
• Languages: English
• ISSNs: 1756-1841

Abstract

<abstract abstract-type="main" id="apl12045-abs-0001"> <title>Abstract</title> <sec id="apl12045-sec-0001" sec-type="section"> <title>Aim</title> <p>This study was designed to evaluate iron deficiency as a predisposing factor for resistant oral aphthosis in patients with Behcet's disease (BD).</p> </sec> <sec id="apl12045-sec-0002" sec-type="section"> <title>Methods</title> <p>In a case control study 220 consecutive BD patients with oral aphthosis were enrolled. All patients had been treated for at least 3 months. They were divided into two groups according to their treatment response (75 patients in the Case and 145 in the Control group<italic>)</italic>. Demographic and clinical characteristics of the disease, serum iron, total iron binding capacity and serum ferritin were determined in each patient. We used independent <italic>t</italic>‐test and Mann–Whitney <italic>U</italic>‐test to compare the quantitative variables and chi‐square test for qualitative variables. Odds ratio (OR) and confidence interval at 95% (95% CI) were calculated for each item.</p> </sec> <sec id="apl12045-sec-0003" sec-type="section"> <title>Results</title> <p>There was no significant difference between the two groups in demographics or clinical characteristics of the disease. We found iron deficiency in 72 patients (32.7%, 95% CI: 6.2), higher in the Case group than Control (39.2% <italic>vs</italic>. 30.1%; <italic>P </italic>=<italic> </italic>0.17). Despite the higher frequency of iron deficiency in men (26.8% <italic>vs</italic>. 14.5%), the difference was not statistically significant (<italic>P </italic>=<italic> </italic>0.09). Multivariate logistic regression analysis showed that none of the iron deficiency or sex variables could predict the development of resistant oral aphthosis. The OR for iron deficiency was 1.52 (95% CI: 0.81–2.86) and for male sex was 1.04 (95% CI: 0.56–1.91).</p> </sec> <sec id="apl12045-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Despite the higher frequency of iron deficiency in BD patients with resistant oral aphthosis, we were not able to attribute this resistance to this deficiency.</p> </sec> </abstract>