Psychosocial job strain and risk of congenital malformations in offspring—a Danish National cohort study. (5th March 2014)

• Record Type: Journal Article
• Authors: Larsen, AD; Hannerz, H; Thulstrup, AM; Bonde, JP; Obel, C; Hougaard, KS
• Is Part Of: BJOG. Volume 121:Number 7(2014:Jul.)
• Page Start: 830
• Page End: 839
• Publication Date: 2014-03-05
• Subjects: Obstetrics -- Periodicals; Gynecology -- Periodicals; 618
• DOI: 10.1111/1471-0528.12612
• Languages: English
• ISSNs: 1470-0328

Abstract

<abstract abstract-type="main" id="bjo12612-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="bjo12612-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate if maternal exposure to psychosocial job strain at work (high demands and low control) measured by questionnaire early in pregnancy (median week 15) is associated with malformations in the offspring.</p> </sec> <sec id="bjo12612-sec-0002" sec-type="section"> <title>Design</title> <p>Population‐based cohort study.</p> </sec> <sec id="bjo12612-sec-0003" sec-type="section"> <title>Setting</title> <p>The Danish National Birth Cohort.</p> </sec> <sec id="bjo12612-sec-0004" sec-type="section"> <title>Population</title> <p>A cohort of 60 386 singleton children with full information on mother's occupational status, exposure to psychosocial job strain and all covariates during pregnancy.</p> </sec> <sec id="bjo12612-sec-0005" sec-type="section"> <title>Methods</title> <p>Logistic regression analysis was used to calculate the odds of congenital malformations as a function of job strain with adjustment for maternal age, body mass index, parity, smoking, alcohol use, manual versus nonmanual work, maternal serious disease and gestational age at interview.</p> </sec> <sec id="bjo12612-sec-0006" sec-type="section"> <title>Main outcome measures</title> <p>Circulatory malformation, musculoskeletal malformation or any malformation.</p> </sec> <sec id="bjo12612-sec-0007" sec-type="section"> <title>Results</title> <p>Logistic regression analyses, both crude and adjusted, indicated no associations between working under high strain and giving birth to a child with circulatory malformation (adjusted odds ratio [OR] 1.04, 95% confidence interval [95% CI] 0.75–1.44), musculoskeletal malformation (aOR 0.88, 95% CI 0.71–1.10) or any malformation (aOR 0.99, 95% CI 0.85–1.15). Supplementary analyses including restriction to first‐borns and a stratified analysis with respect to manual and nonmanual work did not change the results.</p> </sec> <sec id="bjo12612-sec-0008" sec-type="section"> <title>Conclusions</title> <p>Association between exposure to high job strain during pregnancy and elevated risk of circulatory, muscle and any malformations is not supported by this study.</p> </sec> </abstract>