Are synthetic scaffolds suitable for the development of clinical tissue‐engineered tubular organs?. Issue 7 (2nd August 2013)

• Record Type: Journal Article
• Authors: Del Gaudio, Costantino; Baiguera, Silvia; Ajalloueian, Fatemeh; Bianco, Alessandra; Macchiarini, Paolo
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 7(2014:Oct.)
• Page Start: 2427
• Page End: 2447
• Publication Date: 2013-08-02
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.34883
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Transplantation of tissues and organs is currently the only available treatment for patients with end‐stage diseases. However, its feasibility is limited by the chronic shortage of suitable donors, the need for life‐long immunosuppression, and by socioeconomical and religious concerns. Recently, tissue engineering has garnered interest as a means to generate cell‐seeded three‐dimensional scaffolds that could replace diseased organs without requiring immunosuppression. Using a regenerative approach, scaffolds made by synthetic, nonimmunogenic, and biocompatible materials have been developed and successfully clinically implanted. This strategy, based on a viable and ready‐to‐use bioengineered scaffold, able to promote novel tissue formation, favoring cell adhesion and proliferation, could become a reliable alternative to allotransplatation in the next future. In this article, tissue‐engineered synthetic substitutes for tubular organs (such as trachea, esophagus, bile ducts, and bowel) are reviewed, including a discussion on their morphological and functional properties. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2427–2447, 2014</p> </abstract>