New Antimicrobial and Biocompatible Implant Coating with Synergic Silver–Vancomycin Conjugate Action. Issue 6 (2nd May 2014)

• Record Type: Journal Article
• Authors: Varisco, Massimo; Khanna, Nina; Brunetto, Priscilla S.; Fromm, Katharina M.
• Is Part Of: ChemMedChem. Volume 9:Issue 6(2014:Jun.)
• Page Start: 1221
• Page End: 1230
• Publication Date: 2014-05-02
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19005
• DOI: 10.1002/cmdc.201400072
• Languages: English
• ISSNs: 1860-7179

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Materials foreign to the body are used ever more frequently, as increasing numbers of patients require implants. As a consequence, the numbers of implant‐related infections have grown as well, and with increasing resistance. Treatments often fail; thus, new antibacterial coating strategies are being developed by scientists to avoid, or at least strongly reduce, bacterial adhesion to implant surfaces. In this study, we focused on producing a self‐protective coating combining silver(I) ions and a vancomycin‐derived molecule, intelligent pyridinate vancomycin (IPV), with a synergetic and effective action against bacteria. These Ag^I–IPV conjugate‐coated surfaces are well characterized and exhibit strong bactericidal activity in vitro against <italic>Staphylococci</italic> strains. Furthermore, the released quantities of both drugs from the coated surfaces do not affect their biocompatibility and soft tissue integration. These newly developed Ag^I–IPV conjugate coatings thus represent a possible and efficient protection method against bacterial adhesion and biofilm formation during and after implant surgery.</p> </abstract>