Novel multicore niosomes based on double pH-sensitive mixed micelles for Ginsenoside Rh2 delivery. (June 2014)

• Record Type: Journal Article
• Authors: Chen, Daquan; Yu, Hongyun; Mu, Hongjie; Li, Guisheng; Shen, Yan
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 42:Number 3(2014:Jun.)
• Page Start: 205
• Page End: 209
• Publication Date: 2014-06
• Subjects: Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2013.794358
• Languages: English
• ISSNs: 2169-1401

Abstract

<abstract> <title>Abstract</title> <p>In this study, we report the novel double pH-sensitive mixed micelles to fabricate multicore niosomes for drug delivery. The double pH-sensitive mixed micelles (PMM) were prepared with different pH-sensitive polymers, mPEG2000-Hz-CHEMS and mPEG2000-IS (2:1 w/w). Ginsenoside Rh2-loaded DPMM was mixed with Pluronic F-68, in the aqueous medium, and multicore niosomes were fabricated. The size of multicore niosomes were around 100–300 nm with a high encapsulation efficiency of G-Rh2. The G-Rh2-MCN could release encapsulated G-Rh2 with an accelerated rate under lower pH conditions with lower cytotoxicity and good antitumor efficacy.</p> </abstract>