New coumarin derivatives as carbonic anhydrase inhibitors. (June 2014)

• Record Type: Journal Article
• Authors: Karataş, Mert Olgun; Alici, Bülent; Çakir, Ümit; Çetinkaya, Engin; Demir, Dudu; Ergün, Adem; Gençer, Nahit; Arslan, Oktay
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 42:Number 3(2014:Jun.)
• Page Start: 192
• Page End: 198
• Publication Date: 2014-06
• Subjects: Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2013.794352
• Languages: English
• ISSNs: 2169-1401

Abstract

<abstract> <title>Abstract</title> <p>In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC–MS analyses. Structure activity relationship study showed that <bold>3d</bold> (IC_50: 79 μM for hCA I and 88 μM for hCA II) performed higher inhibitory activity than others.</p> </abstract>