Synthesis and blood glucose lowering activity of some novel benzenesulfonylthiourea derivatives substituted with 4-aryl-1-oxophthalazin-2(1H)yl-ones. (June 2014)

• Record Type: Journal Article
• Authors: Yaseen, Shafiya; Bashir, Rafia; Ovais, Syed; Rathore, Pooja; Samim, Mohammed; Javed, Kalim
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 29:Number 3(2014:Jun.)
• Page Start: 362
• Page End: 366
• Publication Date: 2014-06
• Subjects: Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.3109/14756366.2013.782300
• Languages: English
• ISSNs: 1475-6366

Abstract

<abstract> <title>Abstract</title> <p>Some new benzenesulfonylthiourea derivatives substituted with phthalazones <bold>(2a</bold>–<bold>q)</bold> were synthesized by refluxing the appropriate 4-aryl-1-oxophthalazin-2(1H)yl benzenesulfonamides with isothiocyanate in dry acetone over anhydrous K₂CO₃. All the synthesized compounds were characterized on the basis of IR, ¹H NMR, MS data and elemental analysis. These synthesized compounds <bold>(2a</bold>–<bold>q)</bold> at the dose of 20 mg/kg were tested for antihyperglycemic activity in the glucose-fed hyperglycemic normal rat model and among these compounds <bold>2f</bold> and <bold>2m</bold> showed modest antihyperglycemic activity.</p> </abstract>