Colchicine-responsive protracted gouty arthritis with systemic inflammatory reactions. Issue 3 (May 2014)

• Record Type: Journal Article
• Authors: Nonaka, Fumiaki; Migita, Kiyoshi; Haramura, Tomoko; Sumiyoshi, Remi; Kawakami, Atsushi; Eguchi, Katsumi
• Is Part Of: Modern rheumatology. Volume 24:Issue 3(2014)
• Page Start: 540
• Page End: 543
• Publication Date: 2014-05
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2013.874732
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p>Acute gouty arthritis is a severe but self-limiting arthritis caused by inflammatory responses to urate crystals. Oral colchicines are effective for initial stages or prophylaxis, but generally, colchicines are ineffective for established gouty arthritis. We describe an unusual case of gouty arthritis with systemic inflammatory reactions, including high fever and polymyalgia. Refractory polyarthritis and high fever were eradicated by colchicine treatment. Genetic analysis revealed a heterozygous mutation in exon 2 of the <italic>MEFV</italic> gene (E148Q). This case underscores the possibility that <italic>MEFV</italic> gene mutations may modify the phenotype of gouty arthritis.</p> </abstract>