Increased risk of rhinitis symptoms in subjects with gastroesophageal reflux. (June 2014)

• Record Type: Journal Article
• Authors: Hellgren, Johan; Olin, Anna-Carin; Torén, Kjell
• Is Part Of: Acta oto-laryngologica. Volume 134:Number 6(2014)
• Page Start: 615
• Page End: 619
• Publication Date: 2014-06
• Subjects: Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2014.890739
• Languages: English
• ISSNs: 0001-6489

Abstract

<abstract> <title>Abstract</title> <p> <italic>Conclusion:</italic> This study shows that gastroesophageal reflux and tobacco smoke are associated with adult-onset non-infectious rhinitis (NIR). The results support an association between gastroesophageal reflux and upper airway inflammation. <italic>Objectives:</italic> To examine the incidence of adult-onset NIR in relation to several risk factors. <italic>Methods:</italic> This is a follow-up study of 3307 randomly selected men and women aged 25–75 years from a general population-based sample. At baseline, the subjects were investigated with questionnaires, a pulmonary function test, blood samples, and FE_NO. At follow-up 4 years later, all the subjects were mailed a respiratory questionnaire. The incidence of NIR and associated risk factors, such as smoking, atopy, asthma, cough, obesity, and gastroesophageal reflux, was assessed. <italic>Results:</italic> The response rate at follow-up was 92%. The incidence of new-onset NIR was 14.9/1000 person-years (<italic>n</italic> = 247). In a regression model including age, gender, obesity, asthma, cough, and atopy, both current smoking (OR 1.7, 95% CI 1.2–2.5, <italic>p</italic> = 0.002) and gastroesophageal reflux (OR 2.5, 95% CI 1.4–3.1, <italic>p</italic> &lt; 0.001) were significantly associated with adult-onset NIR.</p> </abstract>