Association of greater intravenous volume infusion with shorter hospitalization for patients with post‐ERCP pancreatitis. Issue 6 (June 2014)

• Record Type: Journal Article
• Authors: Sagi, Sashidhar V; Schmidt, Suzette; Fogel, Evan; Lehman, Glen A; McHenry, Lee; Sherman, Stuart; Watkins, James; Coté, Gregory A
• Is Part Of: Journal of gastroenterology and hepatology. Volume 29:Issue 6(2014:Jun.)
• Page Start: 1316
• Page End: 1320
• Publication Date: 2014-06
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12511
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12511-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>There are no data specifically correlating early intravenous volume infusion (IVI) with the length of hospitalization for postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).</p> </sec> <sec id="jgh12511-sec-0002" sec-type="section"> <title>Methods</title> <p>We conducted a retrospective cohort study of patients admitted within 24 h after ERCP to our institute with PEP. IVI during the first 24 h after ERCP was assessed. Primary outcome was severity of PEP, defined by length of hospitalization according to consensus guidelines: mild ≤ 3, moderate 4–10, and severe > 10 days.</p> </sec> <sec id="jgh12511-sec-0003" sec-type="section"> <title>Results</title> <p>Of 72 eligible patients, 41 (56.9%) had mild and 31 (43.1%) moderate/severe PEP. Both groups had comparable demographics, indications, and procedural factors except patients with moderate/severe PEP were older (median age 49 <italic>vs</italic> 36 years, <italic>P</italic> = 0.05) and more likely to be discharged and readmitted within the first 24 h (41.9% <italic>vs</italic> 14.6%, <italic>P</italic> < 0.01). Patients with mild PEP received significantly greater IVI during the first 24 h (2834 mL [2046, 3570] <italic>vs</italic> 2044 mL [1227, 2875], <italic>P</italic> < 0.02) and 50% more fluid post‐ERCP (2270 mL [1435, 2961] <italic>vs</italic> 1515 [950–2350], <italic>P</italic> < 0.02) compared with those with at least moderate PEP.</p> </sec> <sec id="jgh12511-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In patients with PEP, greater IVI during the first 24 h after ERCP is associated with reduced length of hospitalization. Lower IVI was more commonly observed in individuals who were discharged and then readmitted during the first 24 h.</p> </sec> </abstract>