Inverse relationship between gestational weight gain and glucose uptake in human placenta from female foetuses. Issue 3 (2nd December 2013)

• Record Type: Journal Article
• Authors: Walker, S. P.; Ugoni, A. M.; Lim, R.; Lappas, M.
• Is Part Of: Pediatric obesity. Volume 9:Issue 3(2014:Jun.)
• Page Start: e73
• Page End: e76
• Publication Date: 2013-12-02
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/j.2047-6310.2013.00206.x
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo206-sec-0001" sec-type="section"> <title>Background</title> <p>Maternal obesity and gestational weight gain (GWG) have a significant impact on the <italic>in utero</italic> environment, and thus on foetal development and the health of the offspring later in life.</p> </sec> <sec id="ijpo206-sec-0002" sec-type="section"> <title>Objective</title> <p>The aim of this study was to determine the effect of maternal pre‐existing obesity and maternal GWG on glucose uptake from placentas from male and female offspring.</p> </sec> <sec id="ijpo206-sec-0003" sec-type="section"> <title>Methods</title> <p>Total glucose uptake was measured in placental explants using radio‐labelled glucose.</p> </sec> <sec id="ijpo206-sec-0004" sec-type="section"> <title>Results</title> <p>In the female placentas (<italic>n</italic> = 36), GWG and glucose uptake were significantly negatively correlated (<italic>r</italic> = −0.7, <italic>P</italic> < 0.0001; <italic>n</italic> = 36), and customized birthweight centile correlated with placental glucose uptake (<italic>r</italic> = 0.36, <italic>P</italic> = 0.03) but not GWG. In the male placentas (<italic>n</italic> = 45), GWG and glucose uptake were not related, and customized birthweight centile correlated with GWG (<italic>r</italic> = 0.34, <italic>P</italic> = 0.02; <italic>n</italic> = 45), but not placental glucose uptake.</p> </sec> <sec id="ijpo206-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The female placenta can adapt glucose uptake in the face of excessive GWG. The male placenta showed no evidence of changing glucose uptake in response to maternal GWG.</p> </sec> </abstract>