Crystal structure of a putative quorum sensing‐regulated protein (PA3611) from the Pseudomonas‐specific DUF4146 family. Issue 6 (22nd November 2013)

• Record Type: Journal Article
• Authors: Das, Debanu; Chiu, Hsiu‐Ju; Farr, Carol L.; Grant, Joanna C.; Jaroszewski, Lukasz; Knuth, Mark W.; Miller, Mitchell D.; Tien, Henry J.; Elsliger, Marc‐André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.
• Is Part Of: Proteins. Volume 82:Issue 6(2014)
• Page Start: 1086
• Page End: 1092
• Publication Date: 2013-11-22
• Subjects: Proteins -- Periodicals; Proteins -- Periodicals; 572.6
• DOI: 10.1002/prot.24455
• Languages: English
• ISSNs: 0887-3585

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <italic>Pseudomonas aeruginosa</italic> is an opportunistic pathogen commonly found in humans and other organisms and is an important cause of infection especially in patients with compromised immune defense mechanisms. The <italic>PA3611</italic> gene of <italic>P. aeruginosa</italic> PAO1 encodes a secreted protein of unknown function, which has been recently classified into a small Pseudomonas‐specific protein family called DUF4146. As part of our effort to extend structural coverage of novel protein space and provide a structure‐based functional insight into new protein families, we report the crystal structure of PA3611, the first structural representative of the DUF4146 protein family. Proteins 2014; 82:1086–1092. © 2013 Wiley Periodicals, Inc.</p> </abstract>