Peptide profiling of the route from Mahoney to Sabin, and return. (20th May 2013)

• Record Type: Journal Article
• Authors: Kanduc, Darja; Fasano, Candida; Bavaro, Simona Lucia; Novello, Giuseppe; Lucchese, Guglielmo; Capone, Giovanni
• Is Part Of: Journal of basic microbiology. Volume 54:issue 5(2014:May)
• Page Start: 369
• Page End: 377
• Publication Date: 2013-05-20
• Subjects: Microbiology -- Periodicals; 579
• DOI: 10.1002/jobm.201200642
• Languages: English
• ISSNs: 0233-111X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="jobm201200642-sec-0001" sec-type="section"> <p>In order to define poliovirus (PV) neurovirulence at the molecular level, we comparatively analyze the primary amino acid sequence of Mahoney, a neurovirulent PV strain, versus (i) Sabin, an attenuated PV strain, and (ii) IS1, a PV isolate obtained in temporal association to a paralysis event from a polio vaccinated subject. We identify and describe 12 pentapeptides that, originally present in the Mahoney sequence, are changed in the non‐neurovirulent Sabin strain, and, successively, restored in IS1 strain.</p> </sec> </abstract>