Transoral laser microsurgery in treatment of pT2 and pT3 glottic laryngeal squamous cell carcinoma — results of 391 patients. Issue 6 (2nd September 2013)

• Record Type: Journal Article
• Authors: Canis, Martin; Martin, Alexios; Ihler, Friedrich; Wolff, Hendrik A.; Kron, Martina; Matthias, Christoph; Steiner, Wolfgang
• Is Part Of: Head & neck. Volume 36:Issue 6(2014:Jun.)
• Page Start: 859
• Page End: 866
• Publication Date: 2013-09-02
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23389
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23389-sec-0001" sec-type="section"> <title>Background</title> <p>The purpose of this study was to evaluate oncological and functional results of transoral laser microsurgery (TLM) in patients with T2 and T3 glottic laryngeal squamous cell carcinoma (SCC).</p> </sec> <sec id="hed23389-sec-0002" sec-type="section"> <title>Methods</title> <p>A retrospective chart analysis was carried out. Cases were classified into categories pT2a, pT2b, and pT3. Treatment was exclusively TLM ± selective neck dissection and adjuvant (chemo)radiotherapy.</p> </sec> <sec id="hed23389-sec-0003" sec-type="section"> <title>Results</title> <p>Three hundred ninety‐one patients were treated by TLM; 142 cases were category pT2a, 127 were pT2b, and 122 were pT3. Median follow‐up was 71 months. Five‐year overall, recurrence‐free, and disease specific survival rates were 72.2%, 76.4%, and 93.2% for pT2a tumors, 64.9%, 57.3%, and 83.9% for pT2b tumors, and 58.6%, 57.8%, and 84.1% for pT3 tumors, respectively. Larynx preservation was achieved in 93% (pT2a) and 83% (pT2b and pT3).</p> </sec> <sec id="hed23389-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Results are comparable to open partial or total laryngectomy and superior to primary (chemo)radiotherapy. TLM results in a lower morbidity and superior function compared to standard treatment. © 2013 Wiley Periodicals, Inc. <italic>Head Neck</italic> 36: 859–866, 2014</p> </sec> </abstract>