Triterpene Saponins from the Roots of Ilex asprella. Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Lei, Yu; Shi, She‐Po; Song, Yue‐Lin; Bi, Dan; Tu, Peng‐Fei
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 5(2014:May)
• Page Start: 767
• Page End: 775
• Publication Date: 2014-05
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201300155
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Six new triterpene saponins, ilexasprellanosides A–F (<bold>1</bold>–<bold>6</bold>, resp.), together with eleven known compounds were isolated from the roots of <italic>Ilex asprella.</italic> The new saponins were characterized as ursa‐12, 18‐dien‐28‐oic acid 3‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐xylopyranoside (<bold>1</bold>), 19<italic>α</italic>‐hydroxyursolic acid 3‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐(2′‐<italic>O</italic>‐acetylxylopyranoside) (<bold>2</bold>), 19<italic>α</italic>‐hydroxyursolic acid 3‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐glucuronopyranoside (<bold>3</bold>), 3<italic>β</italic>, 19<italic>α</italic>‐dihydroxyolean‐12‐en‐23, 28‐dioic acid 28‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐glucopyranoside (<bold>4</bold>), 19<italic>α‐</italic>hydroxyoleanolic acid 3‐<italic>O‐β</italic>‐<sc>D</sc>‐(2′‐<italic>O</italic>‐acetylxylopyranoside) (<bold>5</bold>), 19<italic>α</italic>‐hydroxyoleanolic acid 3‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐glucuronopyranoside (<bold>6</bold>). The structures of the new compounds were elucidated by analysis of their spectroscopic data and chemical degradation. Compounds <bold>2, 4</bold>, oleanolic acid 3‐<italic>O</italic>‐<italic>β</italic>‐<sc>D</sc>‐glucuronopyranoside, 3‐<italic>β</italic>‐acetoxy‐28‐hydroxyurs‐12‐ene, and pomolic acid showed significant cytotoxic activities against human tumor cell line A549 (<italic>IC</italic><sub>50</sub> values of 1.87, 2.51, 1.41, 3.24, and 5.63 μ<sc>M</sc>, resp.).</p> </abstract>