Three New Phenylpropanoids from the Roots of Piper taiwanense and Their Inhibitory Activities on Platelet Aggregation and Mycobacterium tuberculosis. Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Chen, Si; Cheng, Ming‐Jen; Wu, Chin‐Chung; Peng, Chien‐Fang; Huang, Hung‐Yi; Chang, Hsun‐Shuo; Wang, Chyi‐Jia; Chen, Ih‐Sheng
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 5(2014:May)
• Page Start: 792
• Page End: 799
• Publication Date: 2014-05
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201300208
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Bioassay‐guided fractionation of the active AcOEt‐soluble fraction from the roots of <italic>Piper taiwanense</italic> has led to the isolation of two new phenylpropanoids, taiwanensols A and B (<bold>1</bold> and <bold>2</bold>, resp.), a new natural product, taiwanensol C (<bold>3</bold>), and 3‐acetoxy‐4‐hydroxy‐1‐allylbenzene (<bold>4</bold>). The compounds were obtained as two isomer mixtures (<bold>1</bold>/<bold>2</bold> and <bold>3</bold>/<bold>4</bold>, resp.). Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR spectroscopy and mass spectrometry, and by the comparison of their NMR data with those of related compounds. Compounds <bold>1</bold>–<bold>4</bold> were evaluated for their antiplatelet and antitubercular activities. The mixtures <bold>1</bold>/<bold>2</bold> and <bold>3</bold>/<bold>4</bold> showed potent inhibitory activities against platelet aggregation induced by collagen, with <italic>IC</italic>₅₀ values of 35.2 and 8.8 μ<sc>M</sc>, respectively. In addition, <bold>1</bold>/<bold>2</bold> and <bold>3</bold>/<bold>4</bold> showed antitubercular activities against <italic>Mycobacterium tuberculosis</italic> H37Rv, with <italic>MIC</italic> values of 30.0 and 48.0 μg/ml, respectively.</p> </abstract>