Adjusting the HIV prevalence for non‐respondents using mortality rates in an open cohort in northwest Tanzania. Issue 6 (21st March 2014)

• Record Type: Journal Article
• Authors: Tenu, Filemon; Isingo, Raphael; Zaba, Basia; Urassa, Mark; Todd, Jim
• Is Part Of: Tropical medicine & international health. Volume 19:Issue 6(2014:Jun.)
• Page Start: 656
• Page End: 663
• Publication Date: 2014-03-21
• Subjects: Tropical medicine -- Periodicals; Public health -- Periodicals; 616.988
• DOI: 10.1111/tmi.12304
• Languages: English
• ISSNs: 1360-2276

Abstract

<abstract abstract-type="main" id="tmi12304-abs-0001"> <title>Abstract</title> <sec id="tmi12304-sec-0001" sec-type="section"> <title>Objective</title> <p>To estimate HIV prevalence in adults who have not tested for HIV using age‐specific mortality rates and to adjust the overall population HIV prevalence to include both tested and untested adults.</p> </sec> <sec id="tmi12304-sec-0002" sec-type="section"> <title>Methods</title> <p>An open cohort study was established since 1994 with demographic surveillance system (DSS) and five serological surveys conducted. Deaths from Kisesa DSS were used to estimate mortality rates and 95% confidence intervals by HIV status for 3‐ 5‐year periods (1995–1999, 2000–2004, and 2005–2009). Assuming that mortality rates in individuals who did not test for HIV are similar to those in tested individuals, and dependent on age, sex and HIV status and HIV, prevalence was estimated.</p> </sec> <sec id="tmi12304-sec-0003" sec-type="section"> <title>Results</title> <p>In 1995–1999, mortality rates (per 1000 person years) were 43.7 (95% CI 35.7–53.4) for HIV positive, 2.6 (95% CI 2.1–3.2) in HIV negative and 16.4 (95% CI 14.4–18.7) in untested. In 2000–2004, mortality rates were 43.3 (95% CI 36.2–51.9) in HIV positive, 3.3 (95% CI 2.8–4.0) in HIV negative and 11.9 (95% CI 10.5–13.6) in untested. In 2005–2009, mortality rates were 30.7 (95% CI 24.8–38.0) in HIV positive, 4.1 (95% CI 3.5–4.9) in HIV negative and 5.7 (95% CI 5.0–6.6) in untested residents. In the three survey periods (1995–1999, 2000–2004, 2005–2009), the adjusted period prevalences of HIV, including the untested, were 13.5%, 11.6% and 7.1%, compared with the observed prevalence in the tested of 6.0%, 6.8 and 8.0%. The estimated prevalence in the untested was 33.4%, 21.6% and 6.1% in the three survey periods.</p> </sec> <sec id="tmi12304-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The simple model was able to estimate HIV prevalence where a DSS provided mortality data for untested residents.</p> </sec> </abstract>