Angiosarcoma successfully treated with liver transplantation and sirolimus. (19th March 2014)

• Record Type: Journal Article
• Authors: Xue, Megan; Masand, Prakash; Thompson, Patrick; Finegold, Milton; Leung, Daniel H.
• Is Part Of: Pediatric transplantation. Volume 18:Number 4(2014:Jun.)
• Page Start: E114
• Page End: E119
• Publication Date: 2014-03-19
• Subjects: Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.12245
• Languages: English
• ISSNs: 1397-3142

Abstract

<abstract abstract-type="main" id="petr12245-abs-0001"> <title>Abstract</title> <p>Malignant liver tumors represent approximately 1% of malignancies in children. HA is a high‐grade tumor of endothelial cells that is even more rare in the pediatric population. HA has a limited response to chemotherapy, radiation and resection with universal tumor recurrence with LT and nearly 100% mortality by 18 months. This is the first reported successful case of hepatic angiosarcoma in a child who was treated by LT in combination with sirolimus. Sirolimus antagonizes the mTOR pathway, which regulates cell proliferation, differentiation, and migration, and is being studied as an anti‐neoplastic agent for solid tumors.</p> </abstract>