Gold Nanorod‐Assembled PEGylated Graphene‐Oxide Nanocomposites for Photothermal Cancer Therapy. (5th December 2013)

• Record Type: Journal Article
• Authors: Dembereldorj, Uuriintuya; Choi, Seon Young; Ganbold, Erdene‐Ochir; Song, Nam Woong; Kim, Doseok; Choo, Jaebum; Lee, So Yeong; Kim, Sehun; Joo, Sang‐Woo
• Is Part Of: Photochemistry and photobiology. Volume 90:Number 3(2014:May/Jun.)
• Page Start: 659
• Page End: 666
• Publication Date: 2013-12-05
• Subjects: Photochemistry -- Periodicals; Light -- Physiological effect -- Periodicals; 541.35
• DOI: 10.1111/php.12212
• Languages: English
• ISSNs: 0031-8655

Abstract

<abstract abstract-type="main" id="php12212-abs-0001"> <title>Abstract</title> <p>Gold nanorod‐attached PEGylated graphene‐oxide (AuNR‐PEG‐GO) nanocomposites were tested for a photothermal platform both <italic>in vitro</italic> and <italic>in vivo</italic>. Cytotoxicity of AuNR was reduced after encapsulation with PEG‐GO along with the removal of cetyltrimethylammonium bromide (CTAB) from AuNR by HCl treatment. Cellular internalization of the CTAB‐eliminated AuNR‐PEG‐GO nanocomposites was examined using dark‐field microscopy (DFM), confocal Raman microscopy and transmission electron microscopy (TEM). To determine the photothermal effect of the AuNR‐PEG‐GO nanocomposites, A431 epidermoid carcinoma cells were irradiated with Xe‐lamp light (60 W cm⁻²) for 5 min after treatment with the AuNR‐PEG‐GO nanocomposites for 24 h. Cell viability significantly decreased by ~40% when the AuNR‐PEG‐GO‐encapsulated nanocomposites were irradiated with light as compared with the cells treated with only the AuNR‐PEG‐GO nanocomposites without any illumination. <italic>In vivo</italic> tumor experiments also indicated that HCl‐treated AuNR‐PEG‐GO nanocomposites might efficiently reduce tumor volumes via photothermal processes. Our graphene and AuNR nanocomposites will be useful for an effective photothermal therapy.</p> </abstract>