Vaccine‐Associated Leptospira Antibodies in Client‐Owned Dogs. (5th March 2014)

• Record Type: Journal Article
• Authors: Martin, L.E.R.; Wiggans, K.T.; Wennogle, S.A.; Curtis, K.; Chandrashekar, R.; Lappin, M.R.
• Is Part Of: Journal of veterinary internal medicine. Volume 28:Number 3(2014:May/Jun.)
• Page Start: 789
• Page End: 792
• Publication Date: 2014-03-05
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12337
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12337-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12337-sec-0001" sec-type="section"> <title>Background</title> <p>Long‐term microscopic agglutination test (MAT) results after vaccination with 4‐serovar <italic>Leptospira</italic> vaccines are not available for all vaccines used in client‐owned dogs.</p> </sec> <sec id="jvim12337-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>To determine antibody responses of client‐owned dogs given 1 of 4 commercially available <italic>Leptospira</italic> vaccines.</p> </sec> <sec id="jvim12337-sec-0003" sec-type="section"> <title>Animals</title> <p>Healthy client‐owned dogs (n = 32) with no history of <italic>Leptospira</italic> vaccination for at least the previous year.</p> </sec> <sec id="jvim12337-sec-0004" sec-type="section"> <title>Methods</title> <p>Dogs were given 1 of 4 <italic>Leptospira</italic> vaccines on week 0 and then approximately on week 3 and week 52. Sera were collected before vaccine administration on week 0 and then within 3 days of week 3, within 2 days of week 4, and approximately on weeks 7, 15, 29, 52, and 56. Antibody titers against <italic>Leptospira</italic> serovars <italic>bratislava</italic>, <italic> canicola</italic>, <italic> grippotyphosa</italic>, <italic> hardjo</italic>, <italic> icterohemorrhagiae</italic>, and <italic>pomona</italic> and were determined by MAT.</p> </sec> <sec id="jvim12337-sec-0005" sec-type="section"> <title>Results</title> <p>When compared among vaccines, MAT results varied in maximal titers, the serovars inducing maximal titers, and the time required to reach maximal titers. Each vaccine induced at least some MAT titers ≥1 : 800. Most dogs were negative for antibodies against all serovars 1 year after vaccination, and anamnestic responses were variable.</p> </sec> <sec id="jvim12337-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>Dogs vaccinated with <italic>Leptospira</italic> vaccines have variable MAT titers over time, and antibodies should not be used to predict resistance to <italic>Leptospira</italic> infection. MAT titers ≥1 : 800 can develop after <italic>Leptospira</italic> spp. vaccination, which can complicate the clinical diagnosis of leptospirosis.</p> </sec> </abstract>