A Randomized Study Assessing the Effect of Diet in Cats with Hypertrophic Cardiomyopathy. (3rd April 2014)

• Record Type: Journal Article
• Authors: Freeman, L.M.; Rush, J.E.; Cunningham, S.M.; Bulmer, B.J.
• Is Part Of: Journal of veterinary internal medicine. Volume 28:Number 3(2014:May/Jun.)
• Page Start: 847
• Page End: 856
• Publication Date: 2014-04-03
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.12352
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim12352-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim12352-sec-0001" sec-type="section"> <title>Background</title> <p>Diet might influence progression of hypertrophic cardiomyopathy (HCM).</p> </sec> <sec id="jvim12352-sec-0002" sec-type="section"> <title>Objective</title> <p>To investigate whether diet composition could alter clinical, biochemical, or echocardiographic variables in cats with HCM.</p> </sec> <sec id="jvim12352-sec-0003" sec-type="section"> <title>Animals</title> <p>Twenty‐nine cats with HCM (International Small Animal Cardiac Health Council stage 1b) examined at a university teaching hospital.</p> </sec> <sec id="jvim12352-sec-0004" sec-type="section"> <title>Methods</title> <p>Randomized, placebo‐controlled trial. After physical examination, echocardiogram, and blood collection, cats were randomized to 1 of 3 diets, which varied in carbohydrate and fat content and ingredients. Measurements were repeated after 6 months.</p> </sec> <sec id="jvim12352-sec-0005" sec-type="section"> <title>Results</title> <p>There were no significant differences among the 3 groups at baseline. After 6 months, there were no significant changes in the primary endpoints, left ventricular free wall (Group A, <italic>P </italic>=<italic> </italic>.760; Group B, <italic>P </italic>=<italic> </italic>.475; Group C, <italic>P </italic>=<italic> </italic>.066) or interventricular septal thickness in diastole (Group A, <italic>P </italic>=<italic> </italic>.528; Group B, <italic>P </italic>=<italic> </italic>.221; Group C, <italic>P </italic>=<italic> </italic>.097). Group A had significant increases in BUN (<italic>P </italic>=<italic> </italic>.008) and cholesterol (<italic>P </italic>=<italic> </italic>.021), while Group B had significant increases in BUN (<italic>P </italic>=<italic> </italic>.008), cholesterol (<italic>P </italic>=<italic> </italic>.007), and triglycerides (<italic>P </italic>=<italic> </italic>.005), and significant decreases in NT‐proBNP (<italic>P </italic>=<italic> </italic>.013) and hs‐troponin I (<italic>P </italic>=<italic> </italic>.043). Group C had significant decreases in body weight (<italic>P </italic>=<italic> </italic>.021), left atrial dimension (<italic>P </italic>=<italic> </italic>.035), interventricular septal thickness in systole (<italic>P </italic>=<italic> </italic>.038), and liver enzymes (<italic>P </italic>=<italic> </italic>.034–.038).</p> </sec> <sec id="jvim12352-sec-0006" sec-type="section"> <title>Conclusions and Clinical Importance</title> <p>These data suggest that diet might influence some clinical, biochemical, and echocardiographic variables in cats with HCM.</p> </sec> </abstract>