Assessing the Accuracy and Reproducibility of Computer‐Assisted Analysis of 123I‐FP‐CIT SPECT Using BasGan (V2). Issue 3 (16th January 2013)

• Record Type: Journal Article
• Authors: Skanjeti, A.; Angusti, T.; Iudicello, M.; Dazzara, F.; Delgado Yabar, G. M.; Trevisiol, E.; Podio, V.
• Is Part Of: Journal of neuroimaging. Volume 24:Issue 3(2014)
• Page Start: 257
• Page End: 265
• Publication Date: 2013-01-16
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12008
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="jon12008-sec-0010" sec-type="section"> <title>BACKGROUND AND PURPOSE</title> <p>Over the last two decades <sup>123</sup>I‐FP‐CIT‐SPECT, has been used to discriminate neurodegenerative Parkinsonian syndrome from other diseases. BasGan is a freely available software that assists <sup>123</sup>I‐FP‐CIT‐SPECT evaluation by estimating semiquantitative values for each basal nucleus and compares the results to a database of healthy subjects. The aims of this study were: (1) to assess the accuracy of qualitative analysis and of semiquantitative, BasGan‐assisted evaluations of <sup>123</sup>I‐FP‐CIT‐SPECT; (2) to compare the accuracy of both methods when applied to "doubtful" cases; (3) to appreciate the reproducibility of the BasGan‐assisted evaluations.</p> </sec> <sec id="jon12008-sec-0020" sec-type="section"> <title>MATERIALS AND METHODS</title> <p>Seventy‐eight patients were included in this 4‐year follow‐up study. The diagnostic cut‐off for semiquantitative uptake values of each basal nucleus was determined based on ROC curves analysis. Accuracy scores were calculated for the entire population and for "doubtful" cases. Intra‐ and interoperator reproducibility was assessed.</p> </sec> <sec id="jon12008-sec-0030" sec-type="section"> <title>RESULTS</title> <p>Accuracy of the software‐assisted analyses was high for data from each nucleus. In "doubtful" exams accuracy was higher when using BasGan as opposed to relying solely on visual assessment. Intra‐ and interoperator reproducibility of the BasGan‐assisted evaluations was good to excellent.</p> </sec> <sec id="jon12008-sec-0040" sec-type="section"> <title>CONCLUSION</title> <p>BasGan‐assisted evaluations of <sup>123</sup>I‐FP‐CIT‐SPECT were very useful, particularly in "doubtful" cases. Multicenter studies are mandatory before routine use of BasGan.</p> </sec> </abstract>