A Clinical Review on Extreme Hypofractionated Stereotactic Body Radiation Therapy for Localized Prostate Cancer Using Nonrobotic Linear Accelerators. (28th May 2014)

• Record Type: Journal Article
• Authors: Macias, Victor A.; Perez-Romasanta, Luis A.
• Is Part Of: Cancer investigation. Volume 32:Number 5(2014)
• Page Start: 191
• Page End: 196
• Publication Date: 2014-05-28
• Subjects: Cancer -- Periodicals; Oncology -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- Periodicals; 616.994
• DOI: 10.3109/07357907.2014.896015
• Languages: English
• ISSNs: 0735-7907

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Seven phase I–II studies fell within the inclusion criteria. Details on the radiotherapy technique, patient selection, fractionation scheme, exclusion criteria, treatment toxicity, quality-of-life, and tumor control were collected. The studies provide encouraging results of acute and late toxicity, with rare grade 3 events, that seem comparable to robotic SBRT. The biochemical disease-free survival rates look promising, but most patients belong to the low-risk group. The trials are limited by a short follow-up, small number of patients, and different approaches in prescribing dose and defining the acceptable dose heterogeneities. Currently, nonrobotic SBRT regimens should be used in the context of clinical trials.</bold> </p> </abstract>