Bradykinin B1 receptor-mediated vasodilation is impaired in myometrial arteries from women with pre-eclampsia. (May 2014)

• Record Type: Journal Article
• Authors: Moyes, Amie J.; Gray, Gillan A.; Denison, Fiona C.
• Is Part Of: Hypertension in pregnancy. Volume 33:Number 2(2014)
• Page Start: 177
• Page End: 190
• Publication Date: 2014-05
• Subjects: Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.3109/10641955.2013.846368
• Languages: English
• ISSNs: 1064-1955

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: To investigate the vascular functional activity, localisation and expression of B₁ and B₂ kinin receptors in normal pregnancy and pre-eclampsia. <italic>Methods</italic>: Kinin receptor-mediated relaxation of myometrial arteries was assessed using wire myography. Immunohistochemical staining and gene expression of kinin receptors in the myometrium was determined. <italic>Results</italic>: B₂ receptor-mediated relaxation was reduced in pre-eclampsia. B₁ receptor-mediated relaxation was observed in a proportion of healthy women and was impaired in pre-eclampsia. Receptor expression and localisation was unaltered in pre-eclampsia. <italic>Conclusion</italic>: Here, we demonstrate a novel B₁ receptor-mediated vasodilatation in healthy myometrial vessels that is absent in pre-eclampsia.</p> </abstract>