IL-17A and IL-17F genes variants and susceptibility to childhood asthma in Tunisia. (May 2014)

• Record Type: Journal Article
• Authors: Maalmi, Haifa; Beraies, Anissa; Charad, Rihab; Ammar, Jamel; Hamzaoui, Kamel; Hamzaoui, Agnès
• Is Part Of: Journal of asthma. Volume 51:Number 4(2014)
• Page Start: 348
• Page End: 354
• Publication Date: 2014-05
• Subjects: Asthma -- Periodicals; 616.238005
• DOI: 10.3109/02770903.2013.876647
• Languages: English
• ISSNs: 0277-0903

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives</italic>: IL-17A and IL-17F are new pro-inflammatory cytokines implicated in neutrophilic inflammation and thus, involved in the pathogenesis of asthma. We investigated the possible association among asthma and <italic>IL-17A</italic> -197G/A (rs2275913), <italic>IL-17F</italic> 7488A/G (rs763780) and <italic>IL-17F</italic> 7383A/G (rs2397084).</p> <p> <italic>Methods</italic>: The study was performed in 171 patients with asthma (mean age 9.5 years, 105 boys, and 66 girls) and 171 healthy individuals matched with patients in age and sex. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to detect genes' polymorphisms.</p> <p> <italic>Results: IL-17A</italic> -197G/A and <italic>IL-17F</italic> 7383A/G were associated with asthma in children (p = 0.008, <italic>p</italic> = 0.001, respectively). No association was found with <italic>IL-17F</italic> 7488A/G polymorphism. Haplotype analysis revealed a significant association between GA and AG haplotypes and asthma (<italic>p</italic> = 0.004, <italic>p</italic> = 0.02). When patients were stratified according to the atopic status, no significant association was detected with any of the three studied variants.</p> <p> <italic>Conclusion</italic>: Our results suggested that SNPs in <italic>IL-17A</italic> and <italic>IL-17F</italic> confer susceptibility to childhood asthma in Tunisia.</p> </abstract>