Helicobacter pylori infection is not correlated with subclinical thrombocytopenia: A cross-sectional study. (May 2014)

• Record Type: Journal Article
• Authors: Samson, Annette D.; Schipperus, Martin R.; Langers, Alexandra M. J.; Dekkers, Olaf M.
• Is Part Of: Platelets. Volume 25:Number 3(2014:May)
• Page Start: 221
• Page End: 223
• Publication Date: 2014-05
• Subjects: Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.3109/09537104.2013.803063
• Languages: English
• ISSNs: 0953-7104

Abstract

<abstract> <title>Abstract</title> <p>In a small percentage of patients with immune thrombocytopenia (ITP), <italic>H. pylori</italic> eradication has a positive effect on platelet counts. Whether <italic>H. pylori</italic> infection is associated with a lower thrombocyte count in persons without clinical ITP is unknown. We performed a cross-sectional study to compare thrombocyte count between <italic>H. pylori</italic> infected (<italic>n</italic> = 108) and <italic>H. pylori</italic> non-infected patients (<italic>n</italic> = 600) who underwent a diagnostic gastroscopy. The mean thrombocyte count in <italic>H. pylori</italic> negative patients was 257 × 10⁹/l, in <italic>H. pylori</italic> positive patients 252 × 10⁹/l (mean difference 5 × 10⁹/l, 95% CI: −23 to 14). Subgroup analysis did not show significant differences either. In the patient group without apparent comorbidity, there were no subjects with thrombocyte counts &lt;120. In 36 <italic>H. pylori</italic> positive patients in whom data post-eradication was available, platelet counts pre- and post-eradication were similar. In conclusion, this study could not demonstrate a lower thrombocyte count in <italic>H. pylori</italic> infected patients or in subgroups of <italic>H. pylori</italic> infected patients compared to non-infected subjects.</p> </abstract>