Relationship between oxidant and antioxidant activity in hyperemesis gravidarum. (May 2014)

• Record Type: Journal Article
• Authors: Onaran, Yüksel; Kafali, Hasan; Duvan, Candan İltemir; Keskin, Esra; Çelik, Hakim; Erel, Ozcan
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 8(2014:Aug.)
• Page Start: 825
• Page End: 828
• Publication Date: 2014-05
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.842549
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To evaluate oxidant and antioxidant activity in patients with hyperemesis gravidarum (HG) by using serum total antioxidant activity (TAO), total free sulfhydryl (–SH), ceruloplasmin and lipid hydroperoxide (LOOH) levels.</p> <p> <italic>Materials and methods</italic>: In a cross-sectional trial, blood samples were collected from patients with HG (<italic>n</italic> = 25) and healthy pregnant women (<italic>n</italic> = 25) as control group. Serum TAO activities, –SH levels and LOOH levels and ceruloplasmin levels were measured.</p> <p> <italic>Results</italic>: Serum TAO activity was found to be significantly lower (<italic>p</italic> = 0.003) in patients with HG compared with controls. However, serum –SH levels, LOOH levels and ceruloplasmin levels did not change significantly in patients with HG compared to controls.</p> <p> <italic>Conclusion</italic>: Presence of oxidative stress in HG patients depends more on reduced antioxidant activities than increased oxidative stress.</p> </abstract>