Fish oil supplementation increases concentration of adiponectin in healthy dogs. (25th February 2014)

• Record Type: Journal Article
• Authors: Mazaki‐Tovi, M.; Abood, S. K.; Schenck, P. A.
• Is Part Of: Journal of small animal practice. Volume 55:Number 5(2014:May)
• Page Start: 247
• Page End: 253
• Publication Date: 2014-02-25
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12194
• Languages: English
• ISSNs: 0022-4510

Abstract

<abstract abstract-type="main" id="jsap12194-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jsap12194-sec-0001" sec-type="section"> <title>OBJECTIVE</title> <p id="jsap12194-para-0001"> <bold>To determine the effect of fish oil supplementation on circulating concentrations of adiponectin, leptin, insulin, glucose, triglyceride and cholesterol in healthy dogs</bold>.</p> </sec> <sec id="jsap12194-sec-0002" sec-type="section"> <title>METHODS</title> <p id="jsap12194-para-0002"> <bold>Twenty healthy adult dogs were administered 220 mg/kg of a fish oil supplement once daily for 30 days. At baseline, on supplement and 10 to 20 weeks off supplement, dogs were examined, body condition scores determined (range: 4 to 6), body measurements recorded for % body fat calculation and fasted blood samples collected</bold>.</p> </sec> <sec id="jsap12194-sec-0003" sec-type="section"> <title>RESULTS</title> <p id="jsap12194-para-0003"> <bold>Serum concentrations of the measured individual and total n‐3 polyunsaturated fatty acids increased following supplementation (P<0·001). Mean serum adiponectin concentration on supplement was 3·4 µg/mL (95% confidence interval: 0·8 to 6·0; P=0·006) higher than baseline, and 5·3 µg/mL (2·0 to 8·7; P<0·001) higher than off supplement. Concentrations of adiponectin off supplement were not different from baseline. There were no significant differences in weight, body condition scores, % body fat and concentrations of other measured analytes between baseline and on supplement</bold>.</p> </sec> <sec id="jsap12194-sec-0004" sec-type="section"> <title>CLINICAL SIGNIFICANCE</title> <p id="jsap12194-para-0004"> <bold>Fish oil supplementation significantly increased circulating concentration of adiponectin in healthy non‐obese dogs. Further investigation is warranted to determine whether this effect may be extended to obese dogs and to evaluate the potential role of fish oil supplementation in the management of disorders associated with low circulating adiponectin concentrations</bold>.</p> </sec> </abstract>