The association between trauma and melanoma in the Chinese population: a retrospective study. (7th March 2013)

• Record Type: Journal Article
• Authors: Zhang, N.; Wang, L.; Zhu, G.N.; Sun, D.J.; He, H.; Luan, Q.; Liu, L.; Hao, F.; Li, C.Y.; Gao, T.W.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 5(2014:May)
• Page Start: 597
• Page End: 603
• Publication Date: 2013-03-07
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12141
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" xml:lang="en" id="jdv12141-abs-0001"> <title>Abstract</title> <sec id="jdv12141-sec-0001" sec-type="section"> <title>Background</title> <p>The association between trauma and melanoma has been a controversial issue.</p> </sec> <sec id="jdv12141-sec-0002" sec-type="section"> <title>Objectives</title> <p>To analyse the profiles of melanoma, and to determine whether trauma is associated with development of acral melanoma in the Chinese population.</p> </sec> <sec id="jdv12141-sec-0003" sec-type="section"> <title>Patients and Methods</title> <p>Retrospective analysis of 685 cases of cutaneous melanoma in the dermatology departments of Xijing Hospital in northwestern China and Xinan Hospital in southwestern China from 1982 to 2011.</p> </sec> <sec id="jdv12141-sec-0004" sec-type="section"> <title>Results</title> <p>Of the 685 patients included in the study, 437 (63.8%) suffered from melanoma on the extremities. A total of 104 patients (15.2%) exhibited an association between trauma and melanoma. The primary anatomic sites of the tumours were the upper extremities (17, 16.3%), lower extremities (74, 71.2%) and other sites (13, 12.5%). Among these cases, the extremities were with remarkably higher risks of post‐trauma melanoma than the other sites [adjusted odds ratio (OR) 3.968; 95% confidence interval (CI) 2.267–5.592]. Notably, patients in the south part of China were with a stronger risk of post‐trauma melanoma on the lower extremities than those in the north (adjusted OR 1.764; 95% CI 1.192–2.666) part. In addition, a significant higher risk of post‐trauma melanoma on the extremities was observed in the male gender (adjusted OR 1.848; 95% CI 1.186–2.887).</p> </sec> <sec id="jdv12141-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Our findings provide epidemiological evidence for a potential association between traumatic events and melanoma of the extremities, especially the lower limbs, where a history of trauma is more likely.</p> </sec> </abstract>