Comparative study of hyaluronic acid fillers by in vitro and in vivo testing. (16th March 2013)

• Record Type: Journal Article
• Authors: Park, K.Y.; Kim, H.K.; Kim, B.J.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 5(2014:May)
• Page Start: 565
• Page End: 568
• Publication Date: 2013-03-16
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12135
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12135-abs-0001"> <title>Abstract</title> <sec id="jdv12135-sec-0001" sec-type="section"> <title>Background</title> <p>Numerous hyaluronic acid (HA) fillers seem to have similar characteristics, although manufacturers insist that monophasic and biphasic HA fillers are different in many ways. Little information regarding this is available in the literature.</p> </sec> <sec id="jdv12135-sec-0002" sec-type="section"> <title>Objectives</title> <p>To determine characteristics of monophasic fillers vs. biphasic fillers.</p> </sec> <sec id="jdv12135-sec-0003" sec-type="section"> <title>Material and methods</title> <p>We tested three different (two biphasic and one monophasic) HA fillers both <italic>in vitro</italic> and <italic>in vivo</italic>. In the <italic>in vitro</italic> assay, cell toxicity, resistance to enzyme degradation, syringeability and morphology of particles were tested. <italic>In vivo</italic>, the efficacy and safety were investigated in the dorsal skin of hairless mice.</p> </sec> <sec id="jdv12135-sec-0004" sec-type="section"> <title>Results</title> <p>There was no cell toxicity in any of the three HA fillers. Resistance to enzymatic degradation and syringeability were better in the two biphasic HA fillers than in the monophasic filler. In particle morphology test, gel type monophasic HA filler was also found as a particle type, although there was a slight difference. Volume assessment in animal skin was superior with the monophasic than with the two biphasic HA fillers.</p> </sec> <sec id="jdv12135-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Biphasic HA fillers have some advantages in hyaluronidase resistance, syringeability and lower risk for overcorrection, while monophasic HA fillers may be more suitable for volume augmentation due to swelling capacity.</p> </sec> </abstract>