The efficacy of single dose ivermectin in the treatment of hookworm related cutaneous larva migrans varies depending on the clinical presentation. (1st February 2013)

• Record Type: Journal Article
• Authors: Vanhaecke, C.; Perignon, A.; Monsel, G.; Regnier, S.; Bricaire, F.; Caumes, E.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 5(2014:May)
• Page Start: 655
• Page End: 657
• Publication Date: 2013-02-01
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12097
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" id="jdv12097-abs-0001"> <title>Abstract</title> <sec id="jdv12097-sec-0001" sec-type="section"> <title>Background</title> <p>Treatment of hookworm‐related cutaneous larva migrans (HrCLM) with a single dose of oral ivermectin has not been adequately evaluated to date. Response rates reported in three large studies varied from 77% to more than 95%.</p> </sec> <sec id="jdv12097-sec-0002" sec-type="section"> <title>Objectives</title> <p>We evaluated the efficacy of ivermectin in the treatment of HrCLM.</p> </sec> <sec id="jdv12097-sec-0003" sec-type="section"> <title>Methods</title> <p>We retrospectively studied all returning travellers with HrCLM who consulted in our institution. Patients were then treated with a single, 200 μg/kg dose of ivermectin, orally.</p> </sec> <sec id="jdv12097-sec-0004" sec-type="section"> <title>Results</title> <p>Sixty‐two travellers (35 female, 27 male, mean age 35.6 years) with HrCLM and creeping dermatitis were included. Six patients (10%) also had associated hookworm folliculitis. Fifty‐nine patients (95%) completely responded with one ivermectin dose. The response rate was 98% in the 56 patients presenting with only creeping dermatitis and 66% in the six patients presenting with additional hookworm folliculitis (<italic>P</italic> = 0.02).</p> </sec> <sec id="jdv12097-sec-0005" sec-type="section"> <title>Conclusion</title> <p>The efficacy of a single dose of oral ivermectin is higher in patients with only creeping dermatitis than in those with associated hookworm folliculitis.</p> </sec> </abstract>