Atorvastatin plus omega‐3 fatty acid ethyl ester decreases very‐low‐density lipoprotein triglyceride production in insulin resistant obese men. Issue 6 (29th December 2013)

• Record Type: Journal Article
• Authors: Ng, T. W. K.; Ooi, E. M. M.; Watts, G. F.; Chan, D. C.; Barrett, P. H. R.
• Is Part Of: Diabetes, obesity & metabolism. Volume 16:Issue 6(2014:Jun.)
• Page Start: 519
• Page End: 526
• Publication Date: 2013-12-29
• Subjects: Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.12243
• Languages: English
• ISSNs: 1462-8902

Abstract

<abstract abstract-type="main" id="dom12243-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="dom12243-sec-0002" sec-type="section"> <title>Aim</title> <p id="dom12243-para-0002">To test the effect of atorvastatin (ATV) and ATV plus ω‐3 FAEEs on VLDL‐TG metabolism in obese, insulin resistant men.</p> </sec> <sec id="dom12243-sec-0003" sec-type="section"> <title>Methods</title> <p id="dom12243-para-0003">We carried out a 6‐week randomized, placebo‐controlled study to examine the effect of ATV (40 mg/day) and ATV plus ω‐3 FAEEs (4 g/day) on VLDL‐TG metabolism in 36 insulin resistant obese men. VLDL‐TG kinetics were determined using d<sub>5</sub>‐glycerol, gas chromatography–mass spectrometry and compartmental modelling.</p> </sec> <sec id="dom12243-sec-0004" sec-type="section"> <title>Results</title> <p id="dom12243-para-0004">Compared with the placebo, ATV significantly decreased VLDL‐TG concentration (−40%, p < 0.001) by increasing VLDL‐TG fractional catabolic rate (FCR) (+47%, p < 0.01). ATV plus ω‐3 FAEEs lowered VLDL‐TG concentration to a greater degree compared with placebo (−46%, p < 0.001) or ATV monotherapy (−13%, p = 0.04). This was achieved by a reduction in VLDL‐TG production rate (PR) compared with placebo (−32%, p = 0.008) or ATV (−20%, p = 0.03) as well as a reciprocal increase in VLDL‐TG FCR (+42%, p < 0.05) compared with placebo.</p> </sec> <sec id="dom12243-sec-0005" sec-type="section"> <title>Conclusion</title> <p id="dom12243-para-0005">In insulin resistant, dyslipidaemic, obese men, ATV improves VLDL‐TG metabolism by increasing VLDL‐TG FCR. The addition of 4 g/day ω‐3 FAEE to statin therapy provides further TG‐lowering by lowering VLDL‐TG PR.</p> </sec> </abstract>