Effect of 25 (OH) D replacements in patients with primary hyperparathyroidism (PHPT) and coexistent vitamin D deficiency on serum 25(OH) D, calcium and PTH levels: a meta‐analysis and review of literature. (28th January 2014)

• Record Type: Journal Article
• Authors: Shah, Viral N.; Shah, Chirag S.; Bhadada, Sanjay K.; Rao, D. Sudhakar
• Is Part Of: Clinical endocrinology. Volume 80:Number 6(2014:Jun.)
• Page Start: 797
• Page End: 803
• Publication Date: 2014-01-28
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12398
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12398-abs-0001"> <title>Summary</title> <sec id="cen12398-sec-0001" sec-type="section"> <title>Context</title> <p>The safety of vitamin D replacement in subjects with primary hyperparathyroidism (PHPT) and coexistent vitamin D deficiency is not well established.</p> </sec> <sec id="cen12398-sec-0002" sec-type="section"> <title>Objective</title> <p>To evaluate the safety of vitamin D replacement in PHPT.</p> </sec> <sec id="cen12398-sec-0003" sec-type="section"> <title>Data Source</title> <p>Data were searched from Medline, EMBASE, Cochrane CENTRAL and abstracts form annual scientific meetings of various international bone and mineral societies.</p> </sec> <sec id="cen12398-sec-0004" sec-type="section"> <title>Study Selection</title> <p>Studies examining the effect of preoperative vitamin D replacement in patients with PHPT and coexisting vitamin D deficiency, irrespective of year and language of the publication were included in the present meta‐analysis.</p> </sec> <sec id="cen12398-sec-0005" sec-type="section"> <title>Data Extraction</title> <p>Data were extracted from text of the included publications or abstract of conferences.</p> </sec> <sec id="cen12398-sec-0006" sec-type="section"> <title>Data Synthesis</title> <p>Ten studies enrolling 340 subjects with PHPT were analysed in this meta‐analysis. After vitamin D replacement, there was significant increase in 25(OH) D levels by 55·3 nmol/l (95% CI 33·3–77·3), reduction in serum parathyroid hormone levels by 3·5 pmol/l (5·8 to −1·2) without change in serum calcium (−0·08 mmol/l, −0·2 to +0·03) and urinary calcium levels (0·72 mmol/24 h, <italic>P</italic> = 0·2) compared to baseline.</p> </sec> <sec id="cen12398-sec-0007" sec-type="section"> <title>Conclusion</title> <p>Vitamin D replacement in subjects with PHPT and coexistent vitamin D deficiency increase 25 (OH) D and reduce serum PTH significantly without causing hypercalcaemia and hypercalciuria. The finding of the study needs to be confirmed by a large randomized trial in patient with PHPT and coexistent vitamin D deficiency.</p> </sec> </abstract>