Alternative BRAF mutations in BRAF V600E‐negative hairy cell leukaemias. (16th January 2014)

• Record Type: Journal Article
• Authors: Tschernitz, Sebastian; Flossbach, Lucia; Bonengel, Margrit; Roth, Sabine; Rosenwald, Andreas; Geissinger, Eva
• Is Part Of: British journal of haematology. Volume 165:Number 4(2014:May)
• Page Start: 529
• Page End: 533
• Publication Date: 2014-01-16
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.12735
• Languages: English
• ISSNs: 0007-1048

Abstract

<abstract abstract-type="main" id="bjh12735-abs-0001"> <title>Summary</title> <p>The <italic>BRAF</italic> V600E mutation in exon 15 is considered the disease‐defining mutation in hairy cell leukaemia (HCL), but single HCL cases lacking this mutation have been described. In 24 HCL, as well as in 194 various mature B‐ and T‐cell neoplasms, we extended the search for <italic>BRAF</italic> mutations to exon 11. Two V600E‐negative HCL contained novel, potentially functionally relevant mutations in exon 11 (F468C and D449E), while one other HCL was <italic>BRAF</italic> wild‐type in exons 2–17. All non‐HCL lymphomas lacked <italic>BRAF</italic> mutations. We therefore suggest screening of <italic>BRAF</italic> V600E‐negative HCL for alternative exon 11 mutations in the diagnostic setting.</p> </abstract>