Treatment outcome in children and adolescents with relapsed Hodgkin lymphoma – results of the UK HD3 relapse treatment strategy. (7th February 2014)

• Record Type: Journal Article
• Authors: Shankar, Ananth; Hayward, Janis; Kirkwood, Amy; McCarthy, Keith; Hewitt, Martin; Morland, Bruce; Daw, Stephen
• Is Part Of: British journal of haematology. Volume 165:Number 4(2014:May)
• Page Start: 534
• Page End: 544
• Publication Date: 2014-02-07
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.12768
• Languages: English
• ISSNs: 0007-1048

Abstract

<abstract abstract-type="main" id="bjh12768-abs-0001"> <title>Summary</title> <p>The purpose of this national retrospective study was to evaluate the outcome in children with relapsed or primary refractory Hodgkin lymphoma [HL] after a primary chemotherapy alone treatment strategy. Between 2000 and 2005<bold>, </bold> 80 children with relapsed [<italic>n</italic> = 69] or primary refractory [<italic>n</italic> = 11] HL were treated on a standardized treatment protocol of 4–6 cycles of EPIC [etoposide, prednisolone, ifosfa3mide and cisplatin] chemotherapy. Radiotherapy was recommended to all relapsed sites. High dose therapy with stem cell rescue [SCT] was recommended for patients with poor response. The 5‐year overall survival [OS] and progression‐free survival from relapse was 75·8% [64·8–83·9] and 59·9% [48·3–69·7] respectively. Duration of first remission was strongly associated with OS; risk of death was decreased by 53% [Hazard ratio (HR): 0·47, 95% confidence interval (CI): 0·19–1·18] for those with a time from end of treatment to relapse of 3–12 months (compared to &lt;3 months) and reduced by 80% (HR 0·20, 95% CI: 0·04–0·90) for those &gt;12 months after end of treatment. Other poor prognostic factors included advanced stage disease at relapse and B symptoms at first diagnosis. The most important factor associated with salvage failure was time to relapse<bold>.</bold> Survival outcome in children with primary refractory HL is poor.</p> </abstract>